{
    "componentChunkName": "component---src-templates-article-page-tsx",
    "path": "/articles/fibroblasts-as-starting-cells-for-the-generation-of-induced-pluripotent-stem-cells",
    "result": {"data":{"contentfulArticlePage":{"blocksAfter":[{"__typename":"ContentfulCtaBlock","backgroundImage":null,"backgroundOverlay":true,"body":{"raw":"{\"data\":{},\"content\":[{\"data\":{},\"content\":[{\"data\":{},\"marks\":[],\"value\":\"We're ready to support you in your biomedical research efforts. Contact us now and we'll be in touch with you at the earliest opportunity.\",\"nodeType\":\"text\"}],\"nodeType\":\"paragraph\"}],\"nodeType\":\"document\"}","references":[]},"callToActionCaption":"Send","callToActionTarget":null,"callToActionType":"Form","formName":"fingenious-contact","formOptions":["Early Discovery","Pre-Approval R&D","Post-Approval","Samples","Data","Study Participants"],"formOptionsSelection":"Checkbox","formOptionsTranslationKey":"areaOfInterest","htmlElementId":"contact-us-form-fingenious","id":"f48f85e9-6a56-522d-85fd-25b711028181","theme":"light","title":"Contact us"}],"blocksBefore":null,"body":{"raw":"{\"nodeType\":\"document\",\"data\":{},\"content\":[{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"\",\"marks\":[],\"data\":{}},{\"nodeType\":\"hyperlink\",\"data\":{\"uri\":\"https://www.ita-suomenbiopankki.fi/\"},\"content\":[{\"nodeType\":\"text\",\"value\":\"The Biobank of Eastern Finland\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"text\",\"value\":\" offers researchers a unique opportunity to utilize fibroblast-based cell cultures for the generation of induced pluripotent stem cells (iPSCs). This service supports high-quality basic and translational research aimed at understanding disease mechanisms and developing novel, personalized therapeutic approaches.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Fibroblasts are among the most commonly used and reliable starting cell types for iPSC generation. They are readily obtainable, for example through skin biopsies, and are well suited for in vitro culture. Through cellular reprogramming, fibroblasts can be reverted to a pluripotent state, enabling their differentiation into almost any cell type in the human body. Thanks to this versatility, iPSCs represent a key tool in disease modeling, drug response testing, and the development of new therapeutic strategies.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"heading-4\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"The Biobank of Eastern Finland and Fibroblast-Based Research\",\"marks\":[{\"type\":\"bold\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"The Biobank of Eastern Finland supports biomedical research by providing high-quality tissue and cell samples, which can be utilized, among other applications, in fibroblast-based studies. The biobank’s systematically collected sample collections enable long-term research efforts focused on uncovering disease mechanisms and advancing innovative treatment solutions.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Fibroblasts play a central role in maintaining tissue structure and in tissue repair processes. Through fibroblast research, scientists can investigate the biological mechanisms underlying skin, connective tissues, and tissue injury. The fibroblast cell culture services provided by the Biobank of Eastern Finland serve as a concrete bridge between clinical practice, basic research, and therapeutic innovation.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"By combining high-quality biobank materials with expert support, the service strengthens both regional and national research infrastructures and enhances Finland’s position as an internationally competitive research environment.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"“The Biobank of Eastern Finland develops its operations based on the needs of its customers. Finns’ willingness to participate in biobank research that promotes health by donating samples and health data also makes it possible to provide living cells, such as fibroblasts, for research purposes,” says Arto Mannermaa, Director of the Biobank of Eastern Finland.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Prof. Arto Mannermaa, University of Eastern Finland (UEF), School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"“Fibroblasts provide a unique research tool for investigating disease mechanisms. The biobank enables the integration of high-quality samples, genetic data, and medical history with cultivable stem cell lines, which can be further developed and used to test, for example, the effects of drug molecules at the cellular level,” says Ville Leinonen, Vice Dean of the Faculty of Health Sciences at University of Eastern Finland (Research).\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Prof. Ville Leinonen, Vice Dean for Research, University of Eastern Finland.\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Broad Applications of Fibroblasts in Biomedical Research\",\"marks\":[{\"type\":\"bold\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"The use of fibroblasts in research spans a wide range of scientific disciplines. They are employed in studies on wound healing mechanisms, skin and connective tissue disorders, and in modeling diseases of the musculoskeletal system. In addition, fibroblasts serve as a crucial starting material for genetic research, where iPSC technology opens new avenues for the advancement of personalized medicine.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Fibroblasts – Essential Cells of Human Tissues\",\"marks\":[{\"type\":\"bold\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Fibroblasts are among the most important and versatile cell types in the human body. As the primary cells of connective tissue, they participate in nearly all processes related to tissue maintenance, repair, and regeneration. Their relevance extends from everyday wound healing to advanced biomedical research, where they are used to investigate disease mechanisms, develop new treatments, and construct experimental models of tissue function.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Biological Role of Fibroblasts\",\"marks\":[{\"type\":\"bold\"}],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"As the main cellular component of connective tissue, fibroblasts produce collagen, elastin, and other structural elements of the extracellular matrix. These components form the “scaffold” of tissues, providing organs with strength, elasticity, and structural integrity. Fibroblasts are highly responsive to tissue injury: they become rapidly activated in response to wounds or inflammation and contribute to tissue repair by producing new extracellular matrix and supportive structures.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Due to their intrinsic regenerative capacity, fibroblasts play a critical role in many healing processes within the body. Conversely, dysfunctions in fibroblast activity have been linked to chronic wounds, skin and connective tissue diseases, and age-related tissue changes.\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"References\",\"marks\":[],\"data\":{}}]},{\"nodeType\":\"ordered-list\",\"data\":{},\"content\":[{\"nodeType\":\"list-item\",\"data\":{},\"content\":[{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Ashley EA. The precision medicine initiative: a new national effort. \",\"marks\":[],\"data\":{}},{\"nodeType\":\"text\",\"value\":\"Nat Rev Genet. \",\"marks\":[{\"type\":\"italic\"}],\"data\":{}},{\"nodeType\":\"text\",\"value\":\" 2015;16(5):257–258.   \",\"marks\":[],\"data\":{}}]}]},{\"nodeType\":\"list-item\",\"data\":{},\"content\":[{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Avior Y, Sagi I, Benvenisty N. Pluripotent stem cells in disease modelling and drug discovery. \",\"marks\":[],\"data\":{}},{\"nodeType\":\"text\",\"value\":\"Nat Rev Mol Cell Biol.\",\"marks\":[{\"type\":\"italic\"}],\"data\":{}},{\"nodeType\":\"text\",\"value\":\"  2016;17(3):170–182.\",\"marks\":[],\"data\":{}}]}]},{\"nodeType\":\"list-item\",\"data\":{},\"content\":[{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse fibroblasts by defined factors. \",\"marks\":[],\"data\":{}},{\"nodeType\":\"text\",\"value\":\"Cell.  \",\"marks\":[{\"type\":\"italic\"}],\"data\":{}},{\"nodeType\":\"text\",\"value\":\"2006;126(4):663–676.\",\"marks\":[],\"data\":{}}]}]}]},{\"nodeType\":\"paragraph\",\"data\":{},\"content\":[{\"nodeType\":\"text\",\"value\":\"\",\"marks\":[],\"data\":{}}]}]}","references":[]},"fields":{"route":"/articles/fibroblasts-as-starting-cells-for-the-generation-of-induced-pluripotent-stem-cells"},"fullTitle":"Fibroblasts as Starting Cells for the Generation of Induced Pluripotent Stem Cells","metaDescription":{"metaDescription":"Fibroblasts are among the most commonly used and reliable starting cell types for induced pluripotent stem cell (iPSC) generation. The Biobank of Eastern Finland offers researchers a unique opportunity to utilize fibroblast-based cell cultures for the generation of induced pluripotent stem cells (iPSCs). This service supports high-quality basic and translational research aimed at understanding disease mechanisms and developing novel, personalized therapeutic approaches."},"metaImage":{"file":{"url":"//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg"},"gatsbyImageData":{"images":{"sources":[{"srcSet":"//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=640&h=427&q=50&fm=webp 640w,\n//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=1280&h=854&q=50&fm=webp 1280w,\n//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=2560&h=1707&q=50&fm=webp 2560w","sizes":"(min-width: 2560px) 2560px, 100vw","type":"image/webp"}],"fallback":{"src":"//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=2560&h=1707&fl=progressive&q=50&fm=jpg","srcSet":"//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=640&h=427&fl=progressive&q=50&fm=jpg 640w,\n//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=1280&h=854&fl=progressive&q=50&fm=jpg 1280w,\n//images.ctfassets.net/7e3gy8pq6aym/2ZCa40XJ1G9J2D5ax7FjYm/1ac66c0204a806060c09ec252dbdbf83/Kuoppalevy_mikroskoopilla_ISBP.jpg?w=2560&h=1707&fl=progressive&q=50&fm=jpg 2560w","sizes":"(min-width: 2560px) 2560px, 100vw"}},"layout":"constrained","backgroundColor":"#c8c8b8","width":2560,"height":1707}},"metaTitle":"Fibroblasts as Starting Cells for the Generation of Induced Pluripotent Stem Cells","parentPage":{"fields":{"route":"/fingenious-news-and-updates"},"menuTitle":"News"},"publishedAt":"May 22, 2026"}},"pageContext":{"slug":"fingenious/fibroblasts-as-starting-cells-for-the-generation-of-induced-pluripotent-stem-cells","language":"en","intl":{"language":"en","languages":["en"],"messages":{"supportedLanguages.en":"EN","supportedLanguages.fi":"FI","authentication.login":"Login","form.areaOfInterest":"Area of interest","form.body":"Your message","form.consent":"I agree to","form.discovery":"How did you find us?","form.email":"Email","form.name":"Your name","form.organization":"Company or organization","form.policy":"privacy policy","form.required":"Required field","form.success.body":"Our team will contact you soon.","form.success.heading":"We have received your message—thank you for reaching out!","form.topic":"Select topic"},"routed":false,"originalPath":"/articles/fibroblasts-as-starting-cells-for-the-generation-of-induced-pluripotent-stem-cells","redirect":true,"defaultLanguage":"en"},"locale":"en-US"}},
    "staticQueryHashes": ["1648719659","3130670927","3243898050","3265115003","3728338000","471647045","841752961"]}